GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs1577917 | 1 | rs11758849 | chr6:86708262 | SNHG5 | chr6:86386726-86388451:- | -0.52 | -8.95 | 1.6E-17 | Response to antipsychotic treatment |
| BLCA | cis | rs1577917 | 1 | rs11759855 | chr6:86610841 | SNHG5 | chr6:86386726-86388451:- | -0.53 | -9.45 | 3.38E-19 | Response to antipsychotic treatment |
| BLCA | cis | rs6951245 | 1 | rs11761941 | chr7:1097183 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.41 | 1.33E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs6951245 | 1 | rs11763793 | chr7:1094342 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.4 | 1.41E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs6951245 | 1 | rs11763835 | chr7:1094513 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.4 | 1.41E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs6951245 | 1 | rs11764748 | chr7:1094508 | ZFAND2A | chr7:1192544-1199855:- | -0.32 | -3.84 | 0.000141 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs7789940 | 1 | rs11765693 | chr7:75985373 | UPK3B | chr7:76139745-76157197:+ | -0.3 | -6.33 | 6.76E-10 | Multiple sclerosis |
| BLCA | cis | rs6951245 | 1 | rs11766526 | chr7:1101433 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.45 | 1.12E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs6951245 | 1 | rs11767527 | chr7:1097394 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.41 | 1.33E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs6951245 | 1 | rs11768761 | chr7:1069807 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.31 | 2.12E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs6951245 | 1 | rs11770909 | chr7:1086716 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.53 | 7.81E-6 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs11782652 | 1 | rs11782652 | chr8:82653644 | CHMP4C | chr8:82644688-82671746:+ | -0.71 | -7.2 | 3.23E-12 | Epithelial ovarian cancer;Ovarian cancer |
| BLCA | cis | rs1577917 | 1 | rs117907570 | chr6:86601283 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -10.48 | 9.03E-23 | Response to antipsychotic treatment |
| BLCA | cis | rs6951245 | 1 | rs118059236 | chr7:1073202 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.31 | 2.12E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs12748152 | 1 | rs11807824 | chr1:27270338 | GPN2 | chr1:27205873-27216869:- | 0.48 | 4.1 | 5.14E-5 | HDL cholesterol;Triglycerides;LDL cholesterol |